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April 10, 2024: Andrea Mattevi
Dept. Biology and Biotechnology, University of Pavia

The Mattevi lab has recently focused on functional, structural and mechanistic work on oxygen-dependent enzymes, towards new insight into the oxidative modification of chromatin, redox signalling and ROS biology, and robust oxidative biocatalysts. In the past years, the group has determined and published the first three-dimensional structure of a NADPH-dependent oxidase (NOX). More recently, the group became interested in mitochondrial coenzyme Q biosynthesis, as model system to see how enzymes orchestrate their functions in the cell forming metabolons (i.e. “3D metabolism”).

Apr 24, 2024: Eva Wolf
Institute of Molecular Biology (IMB), Johannes Gutenberg University (JGU), Mainz

Many physiological, metabolic and behavioural processes are regulated in a day-time dependent (circadian) manner via circadian clocks. Our goal is to acquire an atomic resolution picture and quantitative understanding of the molecular processes governing circadian rhythms and their synchronisation with the environmental light-dark cycle. To do this, we perform structural, biochemical and biophysical studies on purified clock proteins as well as structure-based functional assays in cell culture.